MEDSCAPE肺动脉高压治疗的比

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MedscapePulmonaryMedicineShorronPulmonaryMedicineCOMMENTARYPAH:ComparingUpfrontTherapiesAndrewShorr,MD,MPHDecember09,05

AndrewShorr,MD,MPH:ThisisAndyShorrfromWashington,DC,withthepulmonarycriticalcareliteratureupdate.IdliketopointouttherecentlypublishedresultsfromtheAMBITIONtrialintheNewEnglandJournalofMedicine.[]

TheAMBITIONtrialfocusedonourapproachtopulmonaryarterialhypertension(PAH).WehaveaplethoraofagentsforPAH,someofwhichhavebeenrecentlyapprovedonlyinthepastyearsbybothUSandEuropeanregulatoryauthorities.Thecurrentlyavailabledrugs—phosphodiesterasetype5(PDE5)inhibitors,endothelialreceptorantagonists(ERAs),andprostacyclinanalogs—targetvariouspathways.Butwehavelittledatathattellushowtousetheseagentsin







































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